The effects of fipronil on emotional and cognitive behaviors in mammals

Fipronil is a phenylpyrazole insecticide that widely used as pesticide and veterinary drug, although studies suggest it could be toxic to mammals. The objectives of this study were examine the pharmacokinetic profile fipronil in mice, dogs, cats, evaluate its effects on emotional cognitive behaviors dogs cats using data obtained from mice. assessment vivo kinetics was conducted mice dogs. We also performed behavioral tests (elevated plus-maze Y-maze) measured levels neurotransmitters exposed fipronil. In addition, vitro metabolism evaluated liver microsomes rats, cats. results revealed distributed throughout body (blood, brain, adipose tissue, liver) after dermal application. It metabolized sulfone primarily liver. show both have longer half-life than indicated affect alter (dopamine striatum serotonin hippocampus) Furthermore, we found low ability metabolize rats. However, further comprehensive are needed determine whether affects when administered To best our knowledge, first verify